For the most part, no. The box sets were made in vast numbers. The ones that are worth the most are the 1st edition (labelled "Battledroids") and the 3rd edition (because it has a bunch of plastic, no-longer produced mechs). You might get lucky and find a collector who would pay a premium because it's still sealed, but that's a crap-shoot.
Myself, I'd break it open and start playing.