I also smiled when our Doug Glendower once had a shot at a mini-interview with Jeph Jacques.
Now that QC has pushed me into this area of the forums, here's a list of what I read regularly, newcomers to this thread in bold:
ActiveGunnerkrigg Court - so glad it's already featured prominently on this thread. Been reading it since it was first linked to by QC (like chapter 4 or 5) and it is easily my all-time favourite. Truly special.
Magellan - this was one of my personal "1st generation" webcomics, I've been reading it since it first became freely accessible, sometime during chapter 1. Note that this went online before the film Sky High was released. :D The guy also has a comic strip that's something of a soap opera with nudists; much more safe for work than one would expect, but I still won't list it here.
The Noob - I was glad to find this as it carried me over Elf Only Inn's hiatus and later demise. Primitive art but very, very funny stuff.
Jump Leads - Alternate universe scifi humour ftw! I almost didn't put this one up as it has sporadic updates at best. But yesterday the rather unprecedented step was taken to post a non-coloured page, so I'm guessing the intention's there to continue.
Questionable Content - I actually feel this one's past its prime. But it's awesome for always having updates, no matter what. And JJ has linked to a few other webcomics that immediately became favourites of mine.
Gisele Lagace - her work is too inane (Penny and Aggie, especially once she left...) or NSFW/mature (uh yeah) to be linked here. I do enjoy some of it (the latter, I guess) immensely, so this is a kudos listing.
Bobby Crosby - I do/did follow some of his stuff, but again, too specific to be listed, and I only check it out sporadically.
Finished/Abandonedanders loves maria - another comic which I found thanks to QC/JJ. This one is borderline nsfw at times, but it is a deeply meaningful comic and doesn't devolve into frivolities and the art also doesn't really qualify for a non-listing. This one is a truly touching story and is actually finished, hence its listing here is satisfying rather than frustrating.
Elf Only Inn - guh, this is the frustrating one. Of course, it won't be as funny these days anymore when forums have lost their.... hah! Not so, considering the place on which I'm posting! :) Elf Only Inn was forum-based humour, went on a loooong hiatus and returned in v2 as MMORPG-based humour. It took a while to get used to the latter, but it was ok (albeit not quite as good as v1), and The Noob has picked up the slack. Still a total bummer to see this one abandoned.
A Heart Made of Glass - finished/abandoned. I've been aware of this one for the best part of a decade, but upon revisiting during the
break-up of hellTM 2 years ago, I found nothing could reflect my feelings as well as this little comic. + listing it here is an homage to an artist whose magnum opus cannot be listed.