On the smaller scale, one focused narrowly on the FWL remnants and nearby periphery in 3085 would be pretty workable, I think. Players taking on Oriente, Marik, Regulus, Tamarind, Andurien, or Canopus, Alphard, or Niops, (or even one of the independent worlds if they want to be brave) with the LC, CC, and RotS looking on the outskirts for the GMs to use as bogeymen. That would be fun.
Dibs on the Marian Hegemony if that were to ever happen, by the way.