So is it a daily league or weekly league and when would a draft of any kind happen?
Head-to-head matches are weekly; you can change your rosters daily, if you wish.
We do an autodraft and typically set it to run a few days before the start of the official season. Our returning teams set their Keepers beforehand - a minimum of 4, maximum of 8 (usually; hasn't been set in stone for this season yet). Team rosters are usually around 22 players.
All teams draft the first round, with expansion teams at the front of the line (order determined randomly) and then sorted by last year's standings, worst>first. Rounds 2-9 are backfilled with Keepers; teams with open slots draft from the FA pool.
I believe there are 11 categories of stats that are used to determine the weekly scores. Lead in a category, get a win at the end of the week. Category wins are 2 pts, ties are 1 pt. Playoffs are the top 'x' teams as determined by overall points (and Division winners).