Sub-Caps can, but the others are too heavy. In general all you'll fire at is up.
TT
Which, basically, means you shouldn't even bother since you've got so little traverse and tracking ability. Shooting straight ahead is the problem that makes Mass Drivers not worth their upkeep, we probably want more than 5 degrees of traverse from our superheavy defenses.
The video games (Mech Commander, MWO) have planetary defense batteries, including mobile ones on Huntress. Since there were no sub-cap weapons at the time of that game's creation, and the Clans don't use them anyways, we have to conclude that those were Mobile Structures hauling around massive Naval Laser turrets. Thankfully, heat dispersion is somewhat easier on a mobile structure than a spaceship-just have a nice big water tank and let it flash-boil off steam with each shot. Or have a engineering crew construct a pond and drive your mobile structure into it until your heat-sinks on the underside are nice and wet. Getting out without being stuck, that's a different problem...
Can you extend a teleoperated missile's range by vectoring it up into space, then diving onto the target?