My main interest in MGAs lies in their usage on aircraft. Mounting an MGA can be tricky, since the item slot limitations means that whichever location carries the MGA, that's probably the only gear you can place in that location.
The air-to-air applications of machine guns and MGAs are pretty limited due to their extremely limited range...but all air-to-ground attacks are made at short range, so the main downside of these guns is rendered irrelevant. As a result, a large MGA can actually give a conventional or aerospace fighter a fairly flexible weapon, able to act as a hole-puncher or crit-seeker, depending on the type and condition of your target.