I've done bases out of lead, sculpey, plaster, plastics, resin and have had great results with each. To make resin worthwhile, I'd make 5-10 molds out of silicon, while I would sandcast 4 lead bases at a time. Sculpey was the easiest, as I could just use a photocopied template, custom fit the mini, and bake several in a used toaster oven. The plastic was easy -I made a sculpey mold and filled it with my glue gun. The same sculpey mold worked with plaster but again, you may as well cast a batch with multiple molds.
I did the lead sand casting after a friend dumped a load of minis and I had no qualms about melting them down, as many were in poor shape or were large dragons that I had no interest in assembling. I used to freelance as a jeweler so I already had the casting rig but if you have access to large amounts of cheap lead and tin, a sand casting kit is cheap and can be used many times.