I personally hope they return or at least most make the journey to the IS, leaving the remnants of the Society to take over Clan space. The Society makes for a great deep periphery faction.
Hopefully the Home Clans cut a bloody swath through the Combine forever shattering it's annoying plot armor leaving that nation no better off than the Capellans at the end of the 4SW.
Then proceed to wipe forever the original invading Clans from the timeline like an evil Marty Mcfly. The Wolves, for the sin of ferro-lamellor plot armor and Wolf Empire (I'll take 12 year romantic fan-fic over the canocity of that name), and numerous other canonous crimes against BT. The Jade Falcons, for never being better than the Wolves, never killing the Wolves-in-Exile nonsense, never going back to the Homeworlds to spank a little rear end when everyone lost their ever-loving mind, and not blasting the Lyran Alliance into oblivion (greatest sin of all) when given the opportunity. I expected so much more from you... *sigh* The Diamond Sharks/Sea Foxes, because they can't make up their mind what to be called, they're Amazon Prime in space-with guns... and have serve no other purpose, not privateers, brigands, or mercenaries, nope space Wal-Mart. The Ghost Bears, because they do nothing, rip the Combine a new one, no; let me sit here and do absolutely nothing. Not channel my inner clan and remind everyone what's makes us cool. Nah. I hope all of the invading Clans are wiped, dying stupidly and humorously.
Let the Home Clans be the new Clans, the TRUE Clans, the we kill stuff because we can Clans; because peace is for the weak, trade and understanding for the short-sighted, comprise for the degenerate. No let all the stinking inner sphere masses know, the iron boot of the TRUE Clans has returned to settle upon the neck of the degenerate, weak-willed, simple minded, monkeys that infest the paradise that is Terra and your taint shall be removed from its blessed shores.
So, yes. I hope the Home Clans return. >:D