Find something that kills Trueborns, all trueborns. Something insidious that gets into the ecosystem and is impossible to totally be rid of. Spread it everywhere, across all your worlds, across every Clan held world you attack. Make the very Inner Sphere they wish to rule a lethal poison to them. Invade all you want, you can never live here, ever.
Been tried, failed to kill them all, their scientists are too smart.
Nukes make them angry and they have more than you
Ortillery requires you to get in system past their warships, and they have more than you. More aerofighters too.
The dishonorable batchall thing works fine as long as your reserve force is three times their reserve force. Break the bid and they'll drop their entire force on you.
The problem with really truly acting dishonorably is it really truly makes clanners mad. They respond to lack of honor without honor rules.
Genocide is your best bet... Preferably executed 100% effectively by drone.