We've had the Genecaste teased since Interstellar Players 1. I could see an expansion in the Home Clans, coupled with some form of Genecaste-type manipulations in the warrior DNA because it's cheaper resource-wise to breed a soldier with integrated chitinous armor than it is to mine minerals and manufacture armor. Perhaps we'd see bio-mechanical infantry and battle armor, building off rules we've already had for VDNIs. I know aliens have been teased and hinted at before, but we've got pieces and parts lying out there now.
The Home Clans will definitely be back in some way, shape, or form. The upcoming ilClan sourcebook might just be them abandoning the Kerensky Cluster and the Homeworlds and going for broke with one last stab at taking Terra while the only things left on Strana Mechty are wrecked OmniMechs and statues of legs saying "look upon my works, ye mighty, and tremble."