Not sure exactly to what extent the Knowles family was known in comics circles in 1988 (pre-AintItCool News/Harry Knowles), but one might suspect that Knowles Information Services is a shout-out.
It's joined by Weinlein's Books (probably a shout-out to Len Wein, co-creator of Wolverine who...wow...died just last month), Keliher's Apartments, a Community Medical Center, and the Cunningham Day-Care Facility (We sit yer kids down in front of the TV and show them looped reruns of Happy Days. Trust me, they love it. Ayyyyyyyyy! Sit on it, Potsie!)