The majority of humanity was genetically engineered in the 22nd and 23rd centuries, creating what James McKenna referred to as, "Homo Stellaris." As noted in ATOW p. 369:
"[Inner Sphere] Life spans are usually quite high, in the
90s and 100s, but instead of being entirely a result of local
medical care, part of this average results from the centuries
when doctors across human space wielded genetic vaccines.
Humans are simply healthier now than before James McKenna
coined his term, “Homo stellaris.""
JHS:Terra, p. 136 noted the changes weren't radical:
"(Readers will have to
forgive me if I do not recognize James’
McKenna’s “homo stellaris” as different
from homo sapiens sapiens. JumpShips,
a few genetic vaccines, and a pretty
speech do not a new species make.)"
However, this wasn't a radical change, nothing like Shadowrun's geneware or bioware. The homo stellaris effort aimed to bolster immune systems against the feared virgin field pandemics of alien worlds.
Even Gulf Breeze's genetic engineering wasn't especially radical: "only minor edits to their joints and cardiovascular systems"'
The Belters of the Terran system apparently use a bit more genetic engineering - more tolerance to zero-G and maybe more life extension edits - but that's not confirmed in canon yet.