There's a bit of reading in the Shadowrun one, generally you'll have a megacorp card for each player with a special ability, a scene card with an ability, and one or more runner cards that you can use which also have abilities. The actual gameplay is that you'll have a challenge card in front of you with a target number, you roll a bunch of D6s (default is 6 at the start of your turn) and need to assign dice to the challenge who's total exactly matches the target number. You can then choose to score the card or flip over another one, rolling only the dice you didn't assign to the prior card. If you can't match a target the next player can choose to roll the remaining dice and pick up the points or start from scratch. If you match a target with all your dice you replenish your dice pool and start a second row of scoring cards that are 2 points each, and then 3 points if you do it again.
The corp and runner cards generally let you roll additional dice and/or pick a specific dice result to be wild. You spend points to buy runners and they're generally one-shot.